Fipronil is a member of the phenylpyrazole family of non-systemic insecticides/acaricides, which acts by blocking the GABA receptor to kill the target parasite on contact.
FRONTLINE Spot-On Dog is effective against flea infestation for approximately two months and against tick infestation for up to one month, depending on the level of environmental challenge. Newly arriving fleas are killed within 24 hours of landing on the animal. Re-treatment may safely be carried out at one month intervals.
FRONTLINE Spot-On Dog is licensed for use as part of a strategy for the treatment of Flea Allergy Dermatitis. For this condition, monthly application to the allergic patient and to other dogs in the household is recommended.
FRONTLINE Spot-On Dog does not prevent all ticks attaching to the animal, but ticks will be killed in the first 24 - 48 hours after attachment, prior to full engorgement and therefore minimising the risk of transmission of disease. Once dead, ticks will often drop off the animal, but any remaining ticks may easily be removed by a gentle pull, preferably using tweezers. There may be an attachment of single ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.
When treating infestations of lice, all in-contact dogs should be treated with an appropriate product at the same time.
Laboratory studies using fipronil have not shown any teratogenic or embryotoxic effect. The safety of the product was demonstrated in breeding, pregnant and lactating bitches treated with multiple consecutive doses with up to 3 times the maximum recommended dose. FRONTLINE Spot-On Dog can be used during pregnancy and lactation.
No adverse effects were observed in target animal safety studies in 8-week old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of adverse effects may increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight. Safety data are not available for use of the product in animals less than 8 weeks of age.
After the topical application of FRONTLINE Spot-On Dog, the product will spread from the site of treatment to cover the entire surface of the animal within 24 hours. After application, absorption of fipronil through the skin is slight.
No known incompatibilities exist for the use of other insecticides or flea control products concurrently with FRONTLINE Spot-On Dog.
Bathing or shampooing the animal up to one hour prior to treatment does not affect the efficacy of the product. Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.
The alcohol carrier may have adverse effects on painted, varnished or other household surfaces or furnishings.